My question may look bit philosophical and nonsense! But I need to know kind of instructions those are not well suitable in high level languages even in c? Or rarely use in the development of software? Like read/write content of CPU registers may useful in debugging programs. And access to cache memory required when developing OS (maybe I am wrong at this point). Is this kind of instruction available languages like Java, Python, C?

I also have a second question:

And Why all high level languages not having same uniform syntax; at-least same standard library interface name? In python there is and. Or operator is almost same as && and ||. I think Python is developed after C but space indentation is compulsory in Python. Why Python does not use brackets {}. I already know this question going to be highly down-voted.